Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease

Neurobiol Aging. 2014 Aug;35(8):1958.e1-2. doi: 10.1016/j.neurobiolaging.2014.03.004. Epub 2014 Mar 5.


We recently showed that mutation of the VPS35 gene can cause late-onset Parkinson's disease. In the present study we sequenced 702 affected subjects from the Mayo Clinic Parkinson's disease patient-control series for the VPS29 and VPS26A/B genes. We identified only 2 rare nonsynonymous variants in the VPS26A p.K93E and VPS29 p.N72H. The results show that mutations in the genes composing the retromer cargo recognition subunit are not a common cause of Parkinson's disease.

Keywords: Genetics; Parkinson's disease and/or Parkinsonism; Retromer; VPS35.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Female
  • Genetic Association Studies*
  • Genetic Variation / genetics*
  • Humans
  • Male
  • Middle Aged
  • Mutation / genetics*
  • Parkinson Disease / genetics*
  • Vesicular Transport Proteins / genetics*
  • Young Adult


  • VPS26A protein, human
  • VPS29 protein, human
  • Vesicular Transport Proteins