High prevalence of Helicobacter pylori infection in Behcet's disease

BMC Gastroenterol. 2014 Mar 31:14:58. doi: 10.1186/1471-230X-14-58.

Abstract

Background: Behcet's disease (BD) is a multisystem disease of unknown etiology. There are several clues which may indicate an ethiopathogenesis role for Helicobacter pylori infection in this disease.

Methods: In a case control study in an out patient department, 48 patients with BD were compared to age, sex matched controls regarding presence of H. pylori infection by serology and urea breath test (UBT).

Results: Ongoing H. pylori infection was more prevalent among patients with BD using result of UBT with odds ratio of 3.1 (95% CI: 1.34 - 7.26, PV < 0.001).

Conclusion: H. pylori infection may have a role in the pathogenesis of BD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Bacterial / immunology*
  • Behcet Syndrome / epidemiology*
  • Breath Tests
  • Case-Control Studies
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Helicobacter Infections / epidemiology*
  • Helicobacter Infections / immunology
  • Helicobacter pylori / immunology*
  • Humans
  • Male
  • Odds Ratio
  • Prevalence
  • Urea / analysis
  • Young Adult

Substances

  • Antibodies, Bacterial
  • Urea