Multiple sclerosis and pregnancy

Rev Neurol (Paris). 2014 Apr;170(4):247-65. doi: 10.1016/j.neurol.2013.09.010. Epub 2014 Mar 28.


The question of pregnancy in patients with multiple sclerosis is regularly raised due to the prevalence of the disease in middle age women. The multiple sclerosis think tank (Groupe de Réflexion sur la Sclérose en Plaques [GRESEP]) decided to develop recommendations on this issue, with consideration to both the impact of multiple sclerosis on pregnancy, and that of pregnancy on the disease. As with topics of previous works, the formal expert consensus method was used. The working group was composed of hospital-based and private practice neurologists. The reading group was composed of neurologists, anaesthetists and obstetricians. Each recommendation is presented with the relevant level of consensus.

Keywords: Accouchement; Allaitement; Analgésie péridurale; Breastfeeding; Clinical practice guidelines; Consensus formalisé d’experts; Delivery; Epidural analgesia; Grossesse; Multiple sclerosis; Pregnancy; Rand Ucla appropriateness method; Recommandations de pratique clinique; Sclérose en plaques.

Publication types

  • Practice Guideline
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Anesthesia
  • Consensus
  • Contraindications
  • Female
  • Humans
  • Immunologic Factors / adverse effects
  • Immunologic Factors / therapeutic use
  • Multiple Sclerosis / complications
  • Multiple Sclerosis / drug therapy*
  • Postpartum Period
  • Pregnancy
  • Pregnancy Complications / therapy*
  • Recurrence


  • Immunologic Factors