Infantile anti-MuSK positive myasthenia gravis in a patient with autoimmune polyendocrinopathy type 3

Ozgur Duman; Resit Koken; R Taner Baran; Senay Haspolat; Haluk Topaloglu

doi:10.1016/j.ejpn.2014.02.006

Infantile anti-MuSK positive myasthenia gravis in a patient with autoimmune polyendocrinopathy type 3

Eur J Paediatr Neurol. 2014 Jul;18(4):526-8. doi: 10.1016/j.ejpn.2014.02.006. Epub 2014 Mar 12.

Authors

Ozgur Duman¹, Resit Koken², R Taner Baran³, Senay Haspolat², Haluk Topaloglu⁴

Affiliations

¹ Department of Pediatric Neurology, Akdeniz University Hospital, Antalya, Turkey. Electronic address: oduman@akdeniz.edu.tr.
² Department of Pediatric Neurology, Akdeniz University Hospital, Antalya, Turkey.
³ Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkey.
⁴ Department of Pediatric Neurology, Hacettepe University Children's Hospital, Ankara, Turkey.

PMID: 24685514
DOI: 10.1016/j.ejpn.2014.02.006

Abstract

Myasthenia gravis (MG) is an autoimmune disorder caused by autoantibodies and related to the muscle nicotinic acetylcholine receptor (AChR) or muscle-specific tyrosine kinase (MuSK). Myasthenia gravis with anti-MuSK antibodies rarely occurs in children. The present article reports a childhood onset case of auto-immune MG with anti-MuSK antibodies, part of autoimmune polyglandular syndrome.

Keywords: Autoimmune; Infant; MuSK; Myasthenia gravis; Polyglandular syndromes.

Publication types

Case Reports

MeSH terms

Autoantibodies / blood*
Humans
Infant
Male
Myasthenia Gravis / blood*
Myasthenia Gravis / complications*
Polyendocrinopathies, Autoimmune / blood*
Polyendocrinopathies, Autoimmune / complications*
Receptor Protein-Tyrosine Kinases / immunology*

Substances

Autoantibodies
Receptor Protein-Tyrosine Kinases