BMP2 shows neurotrophic effects including neuroprotection against neurodegeneration

Neuroreport. 2014 May 28;25(8):549-55. doi: 10.1097/WNR.0000000000000130.

Abstract

In this study, we found that BMP2 exerts neurotrophic effects, including a neuroprotective effect against nocodazole-induced neuritic degeneration, on neuronal cells. We also found that BMP2-induced neurotrophic effects are directly involved in Smad-dependent signaling as well as PI3K/PTEN-Akt-mTOR signaling. Moreover, BMP2-induced neurotrophic effects occur by stabilization of neuronal microtubules. Thus, these findings suggest that BMP2 can be a potential therapeutic target for nerve injury treatment.

MeSH terms

  • Animals
  • Astrocytes / drug effects
  • Astrocytes / physiology
  • Bone Morphogenetic Protein 2 / pharmacology*
  • Brain / cytology
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Coculture Techniques
  • Enzyme Inhibitors / pharmacology
  • Mice
  • Nerve Degeneration / prevention & control*
  • Neurites / drug effects
  • Neuroblastoma / pathology
  • Neurons / drug effects*
  • Neurons / physiology
  • Neuroprotective Agents / pharmacology*
  • PC12 Cells
  • Rats
  • Signal Transduction / drug effects
  • Tubulin / metabolism

Substances

  • Bmp2 protein, rat
  • Bone Morphogenetic Protein 2
  • Enzyme Inhibitors
  • Neuroprotective Agents
  • Tubulin