A method of producing high quality, optically synchronized two-color ultrashort pulses in an active thulium-doped fiber is proposed. We show that sech-shaped femtosecond pulses with essentially different wavelengths can be generated directly from a Tm/Yb-co-doped amplifier: one pulse at about 2 μm and the second pulse with a tunable wavelength up to 2.3 μm, which covers the pump and gain regions of Cr:ZnSe and Cr:ZnS amplifiers. The shortest pulses with durations of 145 fs at 2.25 μm and 125 fs at 2 μm were measured by the FROG (frequency-resolved optical gating) technique.