Prevalence and predictors of poor sleep quality in mild cognitive impairment

Andrew McKinnon; Zoe Terpening; Ian B Hickie; Jennifer Batchelor; Ron Grunstein; Simon J G Lewis; Sharon L Naismith

doi:10.1177/0891988714527516

Prevalence and predictors of poor sleep quality in mild cognitive impairment

J Geriatr Psychiatry Neurol. 2014 Sep;27(3):204-11. doi: 10.1177/0891988714527516. Epub 2014 Mar 31.

Authors

Andrew McKinnon¹, Zoe Terpening², Ian B Hickie², Jennifer Batchelor³, Ron Grunstein⁴, Simon J G Lewis², Sharon L Naismith⁵

Affiliations

¹ Healthy Brain Ageing Clinic, The University of Sydney, Camperdown, NSW, Australia Department of Psychology, Macquarie University, North Ryde, NSW, Australia.
² Healthy Brain Ageing Clinic, The University of Sydney, Camperdown, NSW, Australia.
³ Department of Psychology, Macquarie University, North Ryde, NSW, Australia.
⁴ Woolcock Institute of Medical Research, NSW, Australia.
⁵ Healthy Brain Ageing Clinic, The University of Sydney, Camperdown, NSW, Australia sharon.naismith@sydney.edu.au.

PMID: 24687189
DOI: 10.1177/0891988714527516

Abstract

Aims: To investigate the prevalence of and contributors to poor sleep quality in patients with mild cognitive impairment (MCI).

Methods: Data were collected for 158 patients meeting the criteria for MCI. Measures included the Pittsburgh Sleep Quality Index, Geriatric Depression Scale, and Mini-Mental State Examination. Demographic, lifestyle, medication, and substance use data were also collected.

Results: A total of 63% of patients with MCI demonstrated sleep disturbance, a significantly higher rate than that of the controls (44%; chi-square = 8.77; P = .003). Depressive symptoms, cognition, antidepressant usage, alcohol consumption, age, and education were identified as significant predictors of self-reported sleep quality in patients with MCI (R(2) = .327, F 6,145 = 11.729, P < .0001).

Conclusions: Sleep disturbance occurs in around two-thirds of patients with MCI. Interventions addressing depression, cognition, and substance and medication use may improve sleep quality in MCI.

Keywords: depression; mild cognitive impairment; sleep disturbance; sleep quality.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Case-Control Studies
Cognitive Dysfunction / epidemiology*
Depression / epidemiology
Female
Humans
Male
Middle Aged
Prevalence
Risk Factors
Self Report
Sleep Wake Disorders / epidemiology*
Sleep Wake Disorders / psychology