Microstructure of subretinal drusenoid deposits revealed by adaptive optics imaging

Biomed Opt Express. 2014 Feb 12;5(3):713-27. doi: 10.1364/BOE.5.000713. eCollection 2014 Mar 1.


Subretinal drusenoid deposits (SDD), a recently recognized lesion associated with progression of age-related macular degeneration, were imaged with adaptive optics scanning laser ophthalmoscopy (AO-SLO) and optical coherence tomography (AO-OCT). AO-SLO revealed a distinct en face structure of stage 3 SDD, showing a hyporeflective annulus surrounded reflective core packed with hyperreflective dots bearing a superficial similarity to the photoreceptors in the unaffected retina. However, AO-OCT suggested that the speckled appearance over the SDD rendered by AO-SLO was the lesion material itself, rather than photoreceptors. AO-OCT assists proper interpretation and understanding of the SDD structure and the lesions' impact on surrounding photoreceptors produced by AO-SLO and vice versa.

Keywords: (110.1080) Active or adaptive optics; (110.4500) Optical coherence tomography; (330.5310) Vision - photoreceptors; (330.7329) Visual optics, pathology.