New myxothiazols from the predatory bacterium Myxococcus fulvus

J Antibiot (Tokyo). 2014 Jul;67(7):519-25. doi: 10.1038/ja.2014.31. Epub 2014 Apr 2.

Abstract

Extracts of the predatory bacterium Myxococcus fulvus HKI 722 showed promising antimicrobial activities in the agar diffusion assay. A combined chemical and computational analysis led to the identification of five thiazole-containing antibiotics. Two of the isolated compounds represent previously unrecognized members of the myxothiazol family of natural products. Their antibiotic properties were determined in comparison with those of the known myxothiazols A and Z.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Methacrylates / chemistry
  • Methacrylates / pharmacology
  • Myxococcus / chemistry*
  • Thiazoles / chemistry
  • Thiazoles / pharmacology

Substances

  • Anti-Bacterial Agents
  • Methacrylates
  • Thiazoles
  • myxothiazol