A study of noninvasive positive-pressure mechanical ventilation in the treatment of acute lung injury with a complex critical care ventilator

J Int Med Res. 2014 Jun;42(3):788-98. doi: 10.1177/0300060514522205. Epub 2014 Apr 1.

Abstract

Objective: To test the hypothesis that there would be better clinical outcomes following the treatment of patients with acute lung injury (ALI) using noninvasive positive-pressure mechanical ventilation (NIPPV) delivered via a complex critical care ventilator compared with a conventional mini-ventilator.

Methods: Patients with ALI who required NIPPV were prospectively enrolled and randomly divided between three intervention groups: group A was ventilated using a mini-ventilator; groups B and C were ventilated using a complex critical care ventilator using different settings. Clinical parameters were recorded before and after 8 h of mechanical ventilation.

Results: A total of 51 patients with ALI were enrolled in the study. Clinical parameters in groups B and C underwent greater improvements than those in group A. Group C demonstrated the lowest treatment failure rate (23.5%). Failure rates were highest in group A (58.8%).

Conclusion: The findings of this present study suggest that there were more satisfactory clinical outcomes following the treatment of patients with ALI when NIPPV was delivered using a complex critical care ventilator compared with a conventional mini-ventilator.

Keywords: Noninvasive ventilation; acute lung injury; acute respiratory distress syndrome; mask; mechanical ventilation.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Lung Injury / mortality
  • Acute Lung Injury / pathology
  • Acute Lung Injury / physiopathology
  • Acute Lung Injury / therapy*
  • Adult
  • Critical Care*
  • Female
  • Humans
  • Lung / pathology
  • Lung / physiopathology
  • Male
  • Middle Aged
  • Positive-Pressure Respiration / instrumentation*
  • Positive-Pressure Respiration / methods
  • Prospective Studies
  • Respiratory Function Tests
  • Survival Analysis
  • Treatment Outcome
  • Ventilators, Mechanical*