Celiac disease and risk of fracture in adults--a review

Osteoporos Int. 2014 Jun;25(6):1667-76. doi: 10.1007/s00198-014-2683-8. Epub 2014 Apr 2.


Patients with celiac disease (CD) have low bone mineral density. Evidence of increased fracture risk in these patients is conflicting, and the indication for bone mineral density screening of all adult CD patients is debated. Our aim was to review current published data on fractures in CD. Cross-sectional cohort studies and one case study were identified by searching Medline and Embase. Although the identified studies are heterogeneous and difficult to compare, the overall findings indicate a positive association between CD and risk of fracture. Adult patients with CD should be considered for bone densitometry in order to estimate fracture risk.

Publication types

  • Review

MeSH terms

  • Bone Density / physiology
  • Celiac Disease / complications*
  • Celiac Disease / physiopathology
  • Humans
  • Osteoporosis / etiology
  • Osteoporosis / physiopathology
  • Osteoporotic Fractures / etiology*
  • Osteoporotic Fractures / physiopathology
  • Research Design
  • Risk Factors