Abstract
Background:
The prevalence of idiopathic vulvodynia and proctodynia is high. Pain management with anti-depressants and anti-epileptics may induce undesirable side effects. Therefore, topical baclofen cream and palmitoylethanolamide might be new therapeutic options.
Case:
A 33-year-old woman with intractable chronic vulvar and anal pain had to abstain from sexual intercourse and could neither cycle nor sit for more than 5 min. The patient did not respond to standard treatments. We prescribed a combination of topical baclofen 5 % and palmitoylethanolamide 400 mg, three times daily. After 3 months her symptoms decreased more than 50 % and sexual intercourse was possible again without pain.
Conclusion:
Topical baclofen and palmitoylethanolamide can be a viable treatment option in chronic vulvodynia and proctodynia.
MeSH terms
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Administration, Topical
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Adult
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Amides
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
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Anus Diseases / drug therapy*
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Baclofen / administration & dosage
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Baclofen / therapeutic use*
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Coitus
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Drug Therapy, Combination / methods
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Endocannabinoids / administration & dosage
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Endocannabinoids / therapeutic use*
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Ethanolamines / administration & dosage
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Ethanolamines / therapeutic use*
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Female
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Humans
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Muscle Relaxants, Central / administration & dosage
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Muscle Relaxants, Central / therapeutic use*
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Pain / drug therapy*
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Palmitic Acids / administration & dosage
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Palmitic Acids / therapeutic use*
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Vulvodynia / drug therapy*
Substances
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Amides
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Anti-Inflammatory Agents, Non-Steroidal
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Endocannabinoids
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Ethanolamines
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Muscle Relaxants, Central
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Palmitic Acids
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palmidrol
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Baclofen