Mechanisms and dynamics of nuclear lamina-genome interactions

Curr Opin Cell Biol. 2014 Jun;28:61-8. doi: 10.1016/j.ceb.2014.03.003. Epub 2014 Mar 30.

Abstract

The nuclear lamina (NL) interacts with the genomic DNA and is thought to influence chromosome organization and gene expression. Both DNA sequences and histone modifications are important for NL tethering of the genomic DNA. These interactions are dynamic in individual cells and can change during differentiation and development. Evidence is accumulating that the NL contributes to the repression of transcription. Advances in mapping, genome-editing and microscopy techniques are increasing our understanding of the molecular mechanisms involved in NL-genome interactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / genetics
  • Chromatin / metabolism
  • Chromosomes / metabolism
  • Gene Expression
  • Genome*
  • Humans
  • Nuclear Lamina / genetics
  • Nuclear Lamina / metabolism*

Substances

  • Chromatin