Tumor rupture as an initial manifestation of malignant mesonephric mixed tumor: a case report and review of the literature

Int J Clin Exp Pathol. 2014 Feb 15;7(3):1212-7. eCollection 2014.


Malignant mesonephric mixed tumor (MMMT), or mesonephric carcinosarcoma, is a rare tumor with malignant epithelial and mesenchymal components, and is found mostly in the uterine cervix. While diagnosed at the early stage in most cases, MMMT can have an aggressive course. The clinical significance of the presence of sarcomatous components remains unsettled. We report a case of MMMT of the uterine cervix in a patient who presented with tumor rupture, instead of the common presentation, vaginal bleeding. This unusual presentation has not been reported in the literature. It implies that MMMT may progress rapidly without any prodrome and pose a surgical emergency. Unlike most cervical adenocarcinomas, both mesonephric adenocarcinoma and MMMT are not related to human papilloma virus (HPV) infection. Because mesonephric neoplasms have a different etiology, their prevention, screening, and treatment should be further investigated. Thirteen cases of MMMT reported in the literature are also reviewed.

Keywords: Mesonephric carcinosarcoma; malignant mesonephric mixed tumor; rupture; uterine cervix.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Carcinosarcoma / epidemiology
  • Carcinosarcoma / pathology*
  • Comorbidity
  • Diabetes Mellitus / epidemiology
  • Female
  • Humans
  • Hypertension / epidemiology
  • Mesonephroma / epidemiology
  • Mesonephroma / pathology*
  • Middle Aged
  • Rupture
  • Uterine Cervical Neoplasms / epidemiology
  • Uterine Cervical Neoplasms / pathology*