Multidimensional reaction screening for photochemical transformations as a tool for discovering new chemotypes

J Org Chem. 2014 May 2;79(9):3838-46. doi: 10.1021/jo500190b. Epub 2014 Apr 16.

Abstract

We have developed an automated photochemical microfluidics platform that integrates a 1 kW high-pressure Hg vapor lamp and allows for analytical pulse flow or preparative continuous flow reactions. Herein, we will discuss the use of this platform toward the discovery of new chemotypes through multidimensional reaction screening. We will highlight the ability to discretely control wavelengths with optical filters, allowing for control of reaction outcomes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Microfluidics / instrumentation
  • Molecular Conformation
  • Organic Chemicals / chemical synthesis
  • Organic Chemicals / chemistry*
  • Photochemical Processes

Substances

  • Organic Chemicals