[Results of pregnancies characterized by a decrease in the level of alpha-fetoprotein in the maternal blood]

J Genet Hum. 1989 Jan;37(1):71-5.
[Article in French]


Pregnancy outcome was followed in 123 women showing maternal serum alpha-fetoprotein, less than or equal to 0.50 MOM. In 28 cases AFP was secondarily considered as normal either after ultrasonography and correction of gestation age or after a second sample normal result. In 95 cases AFP level was confirmed lowered; perinatal outcome was normal in 70 cases and abnormal in 25. Among these 25 cases, 3 autosomal trisomies occurred, 2 trisomies 18 and 1 trisomy 21; in the 22 other cases, we observed antepartum risk factors (10 cases with impending premature labor or premature labor, 9 cases with chronic hypertension, 2 cases with Ag HBs hepatitis and 1 case with diabetes).

Publication types

  • English Abstract

MeSH terms

  • Female
  • Follow-Up Studies
  • Humans
  • Pregnancy
  • Pregnancy Complications / blood*
  • Pregnancy Complications / diagnosis
  • Trisomy*
  • Ultrasonography
  • alpha-Fetoproteins / deficiency*


  • alpha-Fetoproteins