Atypical hand, foot, and mouth disease associated with coxsackievirus A6 infection, Edinburgh, United Kingdom, January to February 2014

Euro Surveill. 2014 Mar 27;19(12):20745. doi: 10.2807/1560-7917.es2014.19.12.20745.


In January to February 2014, 16 hand, foot and mouth disease (HFMD) cases were identified in Edinburgh, United Kingdom. All presented with atypical features, with most (n=13) resembling eczema herpeticum or chickenpox. Coxsackievirus A6 (CV-A6) was identified in all the typed cases (n=11). As atypical forms of HFMD associated with CV-A6 are likely to emerge throughout Europe, clinicians should be alert to unusual clinical presentations of HFMD and virologists aware of effective diagnostic testing and enterovirus typing methods.

MeSH terms

  • Adult
  • Chickenpox / etiology
  • Child, Preschool
  • Coxsackievirus Infections / complications*
  • Coxsackievirus Infections / epidemiology
  • Coxsackievirus Infections / virology
  • Diagnosis, Differential
  • Disease Outbreaks
  • Enterovirus A, Human / genetics*
  • Enterovirus A, Human / isolation & purification
  • Female
  • Hand, Foot and Mouth Disease / complications*
  • Hand, Foot and Mouth Disease / epidemiology
  • Hand, Foot and Mouth Disease / virology*
  • Humans
  • Infant
  • Kaposi Varicelliform Eruption / etiology
  • Male
  • Middle Aged
  • RNA, Viral / genetics
  • Real-Time Polymerase Chain Reaction
  • Retrospective Studies
  • Sentinel Surveillance
  • Sequence Analysis, DNA
  • United Kingdom / epidemiology


  • RNA, Viral