Strippers reveal their depressing secrets: removing AMPA receptors

Graham L Collingridge; Stephane Peineau

doi:10.1016/j.neuron.2014.03.019

Strippers reveal their depressing secrets: removing AMPA receptors

Neuron. 2014 Apr 2;82(1):3-6. doi: 10.1016/j.neuron.2014.03.019.

Authors

Graham L Collingridge¹, Stephane Peineau²

Affiliations

¹ Centre for Synaptic Plasticity, University of Bristol, Bristol BS1 3NY, UK. Electronic address: glcollingridge@gmail.com.
² Centre for Synaptic Plasticity, University of Bristol, Bristol BS1 3NY, UK; Inserm U1141/Université Paris Diderot Sorbonne Paris Cité/PremUP, Hôpital Robert Debré, 75019 Paris, France.

PMID: 24698263
DOI: 10.1016/j.neuron.2014.03.019

Abstract

How do microglia regulate synaptic function? In this issue of Neuron, Zhang et al. (2014) describe a novel form of long-term depression of AMPA receptor-mediated synaptic transmission in the hippocampus involving the activation of microglia.

Publication types

Comment

MeSH terms

Animals
Hippocampus / physiology*
Long-Term Synaptic Depression / physiology*
Macrophage-1 Antigen / metabolism*
Microglia / metabolism*
NADPH Oxidases / metabolism*

Substances

Macrophage-1 Antigen
NADPH Oxidases

Grants and funding

MR/K023098/1/MRC_/Medical Research Council/United Kingdom