Higher body mass index in adults at diagnosis of the slowly progressive form of type 1 diabetes mellitus is associated with lower risk HLA genes

Diabetes Res Clin Pract. 2014 Jun;104(3):e69-71. doi: 10.1016/j.diabres.2014.03.009. Epub 2014 Mar 18.

Abstract

We hypothesised that higher body weight, a proposed risk factor for type 1 diabetes mellitus, would be associated with increased penetrance of lower risk genes. In adults at diagnosis of the slowly progressive form of type 1 diabetes mellitus we found that higher body mass index was associated with the absence of the highest risk HLA genes.

Keywords: Body weight; Gene penetrance; HLA; LADA; Type 1 diabetes mellitus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Autoimmune Diseases / diagnosis
  • Autoimmune Diseases / genetics*
  • Body Mass Index*
  • Diabetes Mellitus, Type 1 / diagnosis
  • Diabetes Mellitus, Type 1 / genetics*
  • Female
  • HLA-DQ Antigens / genetics*
  • HLA-DR Antigens / genetics*
  • Humans
  • Male
  • Middle Aged
  • Overweight
  • Risk Factors

Substances

  • HLA-DQ Antigens
  • HLA-DR Antigens