3D bioelectronic interface: capturing circulating tumor cells onto conducting polymer-based micro/nanorod arrays with chemical and topographical control

Small. 2014 Aug 13;10(15):3012-7. doi: 10.1002/smll.201400429. Epub 2014 Apr 3.

Abstract

The three-dimensional (3D) poly(3,4-ethylenedioxythiophene) (PEDOT)-based bioelectronic interfaces (BEIs) with diverse dimensional micro/nanorod array structures, varied surface chemical pro-perties, high electrical conductivity, reversible chemical redox switching, and high optical transparency are used for capturing circulating tumor cells (CTCs). Such 3D PEDOT-based BEIs can function as an efficient clinical diagonstic and therapeutic platform.

Keywords: bioelectronic interface; cancer diagnosis; circulating tumor cells; nanostructured materials; poly(3,4-ethylenedioxythiophene) (PEDOT).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bridged Bicyclo Compounds, Heterocyclic / chemistry*
  • Cell Line, Tumor
  • Cell Separation / instrumentation*
  • Conductometry / instrumentation*
  • Electric Conductivity
  • Equipment Design
  • Equipment Failure Analysis
  • Humans
  • Miniaturization
  • Nanotubes / chemistry*
  • Nanotubes / ultrastructure
  • Neoplastic Cells, Circulating / pathology*
  • Polymers / chemistry*
  • Surface Properties
  • Tissue Array Analysis

Substances

  • Bridged Bicyclo Compounds, Heterocyclic
  • Polymers
  • poly(3,4-ethylene dioxythiophene)