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. 2014 Jul;68(7):321-3.
doi: 10.1002/syn.21744. Epub 2014 Apr 15.

Olfactory tubercle neurons exhibit slow-phasic firing patterns during cocaine self-administration

Brendan M Striano  1 , David J Barker, Anthony P Pawlak, David H Root, Anthony T Fabbricatore, Kevin R Coffey, Joshua P Stamos, Mark O West
Affiliations

Olfactory tubercle neurons exhibit slow-phasic firing patterns during cocaine self-administration

Brendan M Striano et al. Synapse. 2014 Jul.
No abstract available

Keywords: addiction; cocaine; dopamine; ventral striatum.

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Conflict of interest statement

The authors have no financial interests to be disclosed.

Figures

Fig. 1
Fig. 1
A: Schematic representation of wire placements (black dots). Numbers indicate the distance (mm) from bregma. Wires were verified to be >150 μm from all borders. B: An example progressive-reversal firing pattern with a schematic of estimated drug level over the interinfusion interval (black line). The x-axis shows time in relation to the infusion offset (seconds). Y-axis is an average of firing rate across 50 trials.
Fig. 2
Fig. 2
Patterns detected by the principal components analysis. Bold component traces are representative curves of activity within a group of neurons shown to fire similarly (Anderson–Rubin factor scores) and gray traces represent normalized firing rate (z-score) for individual neurons composing each taxon. Time in relation to the infusion offset (seconds) is shown on the x-axis (infusion at time zero). Plots A, B, and C correspond to decreasing (A) and increasing (B–C) progressive reversal (PR) patterns, which appear to be pharmacologically mediated by fluctuations in estimated drug level across the interinfusion interval. Plots D–F represent late-reversal (LR) and early-reversal (ER) patterns which may or may not be linked to pharmacological mediation. Plot G shows traces for neurons that did not load on any of the defined taxa (i.e., those which show no pattern across the interinfusion interval; NC).
See this image and copyright information in PMC

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