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. 2014 Feb;8(2):34-6.
doi: 10.7860/JCDR/2014/7588.4000. Epub 2014 Feb 3.

Apo B/Apo A-I Ratio Is Statistically A Better Predictor of Cardiovascular Disease (CVD) Than Conventional Lipid Profile: A Study From Kathmandu Valley, Nepal

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Free PMC article

Apo B/Apo A-I Ratio Is Statistically A Better Predictor of Cardiovascular Disease (CVD) Than Conventional Lipid Profile: A Study From Kathmandu Valley, Nepal

Hem Kumar Tamang et al. J Clin Diagn Res. .
Free PMC article

Abstract

Background: Apo B and Apo A-I, are structural and functional components of lipoprotein particles that serve as transporters of cholesterol. The apo B/apo A-I ratio reflects the cholesterol transport and has been shown to be strongly related to risk of Myocardial infarction, stroke and other Cardiovascular manifestations.

Materials and methods: Forty five participants with Cardiovascular Disease (CVD) and forty four healthy participants were included from different locations of Kathmandu valley, Nepal. Fasting blood samples were collected from ante-cubital vein and serum samples were used for lipid parameters, apo B and apo A-I levels measurement.

Results: Statistically significant differences were found for apo B/apo A-I ratio, HDL-c and apo B between the groups. The other lipid parameters and lipid ratios such as total cholesterol, triglyceride, low density lipoprotein, TC/HDL-c, TG/HDL-c and LDL-c/HDL-c were not found to be significant.

Conclusion: Apo B/apo A-I ratio seems to have better predictive value than that of classical lipid parameters in cardiovascular risk assessment.

Keywords: Apo B/apo A-I ratio; Cardiovascular disease; Lipid parameters; Predictive value.

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