On the origin of leukemic species

Aparna Vasanthakumar; Lucy A Godley

doi:10.1016/j.stem.2014.03.008

On the origin of leukemic species

Cell Stem Cell. 2014 Apr 3;14(4):421-2. doi: 10.1016/j.stem.2014.03.008.

Authors

Aparna Vasanthakumar¹, Lucy A Godley²

Affiliations

¹ Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.
² Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. Electronic address: lgodley@medicine.bsd.uchicago.edu.

PMID: 24702991
DOI: 10.1016/j.stem.2014.03.008

Abstract

Recent studies (Shlush et al., 2014; Corces-Zimmerman et al., 2014) have demonstrated that leukemias develop from hematopoietic stem cells that acquire preleukemic mutations, allowing clonal expansion and subsequent acquisition of mutations leading to cancer. Preleukemic cells survive chemotherapy and serve as reservoirs for disease, generating new clones and leading to relapse.

Publication types

Comment

MeSH terms

Animals
Clonal Evolution / genetics*
Epigenesis, Genetic / genetics*
Female
Hematopoietic Stem Cells / chemistry*
Hematopoietic Stem Cells / cytology*
Humans
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / pathology*
Models, Biological*
Neoplastic Stem Cells / cytology*
Preleukemia / genetics*