Anti-MOG antibodies in adult patients with demyelinating disorders of the central nervous system

J Neuroimmunol. 2014 May 15;270(1-2):98-9. doi: 10.1016/j.jneuroim.2014.03.001. Epub 2014 Mar 11.


The myelin oligodendrocyte glycoprotein (MOG) is considered as a candidate marker of demyelinating disorders of the central nervous system. Here, sera samples from 48 consecutive Japanese patients with myelitis or optic neuritis (ON), but negative for anti-aquaporin (AQP) 4 antibodies (Abs), and 14 anti-AQP4 Ab-positive patients were tested for anti-MOG Abs using a cell-based immunofluorescence assay with full-length human MOG cDNA. Anti-MOG Abs were detected in four male patients with myelitis or ON. Oveall, 13 neuromyelitis optica-seronegative and all anti-AQP4 Ab-positive patients were negative for anti-MOG Abs. Hence, these findings warrant further examinations in large cohort series.

Keywords: Anti- myelin oligodendrocyte glycoprotein antibodies; Anti-aquaporin 4 antibodies; Cell-based immunofluorescence assay; Multiple sclerosis; Neuromyelitis optica; Optic neuritis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Autoantibodies / blood*
  • Autoantibodies / immunology
  • Autoantigens / immunology
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Male
  • Middle Aged
  • Myelin-Oligodendrocyte Glycoprotein / immunology*
  • Myelitis, Transverse / blood
  • Myelitis, Transverse / immunology*
  • Optic Neuritis / blood
  • Optic Neuritis / immunology*
  • Young Adult


  • Autoantibodies
  • Autoantigens
  • MOG protein, human
  • Myelin-Oligodendrocyte Glycoprotein