In melanoma, Hippo signaling is affected by copy number alterations and YAP1 overexpression impairs patient survival

Pigment Cell Melanoma Res. 2014 Jul;27(4):671-3. doi: 10.1111/pcmr.12249. Epub 2014 May 6.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing* / biosynthesis
  • Adaptor Proteins, Signal Transducing* / genetics
  • Disease-Free Survival
  • Female
  • Gene Dosage*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Melanoma* / genetics
  • Melanoma* / metabolism
  • Melanoma* / mortality
  • Neoplasm Proteins* / biosynthesis
  • Neoplasm Proteins* / genetics
  • Phosphoproteins* / biosynthesis
  • Phosphoproteins* / genetics
  • Protein-Serine-Threonine Kinases* / genetics
  • Protein-Serine-Threonine Kinases* / metabolism
  • Signal Transduction / genetics*
  • Survival Rate
  • Transcription Factors

Substances

  • Adaptor Proteins, Signal Transducing
  • Neoplasm Proteins
  • Phosphoproteins
  • Transcription Factors
  • YAP1 (Yes-associated) protein, human
  • Hippo protein, human
  • Protein-Serine-Threonine Kinases