The genetic basis of gout

Rheum Dis Clin North Am. 2014 May;40(2):279-90. doi: 10.1016/j.rdc.2014.01.009. Epub 2014 Feb 19.


Gout results from deposition of monosodium urate (MSU) crystals. Elevated serum urate concentrations (hyperuricemia) are not sufficient for the development of disease. Genome-wide association studies (GWAS) have identified 28 loci controlling serum urate levels. The largest genetic effects are seen in genes involved in the renal excretion of uric acid, with others being involved in glycolysis. Whereas much is understood about the genetic control of serum urate levels, little is known about the genetic control of inflammatory responses to MSU crystals. Extending knowledge in this area depends on recruitment of large, clinically ascertained gout sample sets suitable for GWAS.

Keywords: ABCG2; Association; Gene; Genome-wide association studies; Gout; SLC2A9; Urate.

Publication types

  • Review

MeSH terms

  • Gene-Environment Interaction
  • Genome-Wide Association Study
  • Glycolysis / genetics
  • Gout / genetics*
  • Humans
  • Hyperuricemia / genetics*
  • Kidney / metabolism*
  • Uric Acid / metabolism*


  • Uric Acid