MR-compatible pedal ergometer for reproducible exercising of the human calf muscle

Abstract

A pneumatic MR-compatible pedal ergometer was designed to perform dynamic contraction exercises of the human calf muscle in a whole-body 3T MR scanner. The set-up includes sensors for monitoring mechanical parameters, such as pedal angle, cadence as well as applied force and power. Actual parameter values during the exercise were presented to the volunteer as a visual feedback to enable real-time self-adjustment of pedal deflection and cadence to the target reference value. Time-resolved dynamic (31)P-MR spectroscopic measurements of phosphocreatine (PCr), inorganic phosphate (Pi) and pH were performed in a pilot experiment before, during, and after the exercise by a single volunteer. Two different load strengths were applied in these experiments (15% and 25% of the maximum voluntary contraction, MVC). As expected, mechanical and metabolic parameters differed for the two load levels. Small variations of the cadence, power and metabolic changes (time constants of PCr depletion and Pi accumulation) during the experiments demonstrate a highly reproducible mechanical output by the volunteer mediated by the ergometer.

Keywords: Calf muscle; Ergometer; Magnetic resonance spectroscopy.