Lipotoxicity, β Cell Dysfunction, and Gestational Diabetes

Cell Metab. 2014 Apr 1;19(4):553-4. doi: 10.1016/j.cmet.2014.03.020.

Abstract

Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed that CMPF directly induces β cell dysfunction.

Publication types

  • Comment

MeSH terms

  • Animals
  • Furans / blood*
  • Humans
  • Insulin-Secreting Cells / pathology*
  • Mitochondria / pathology*
  • Models, Biological*
  • Organic Anion Transporters, Sodium-Independent / metabolism*
  • Propionates / blood*

Substances

  • 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid
  • Furans
  • Organic Anion Transporters, Sodium-Independent
  • Propionates
  • organic anion transport protein 3