Acetyl-CoA synthetase is a conserved regulator of autophagy and life span

Cell Metab. 2014 Apr 1;19(4):555-7. doi: 10.1016/j.cmet.2014.03.021.


Autophagy is essential for the maintenance of cellular homeostasis during periods of stress. Eisenberg and colleagues (Eisenberg et al., 2014) now describe the central and conserved role for acetyl-CoA synthetase in regulating life span in yeast and flies by a mechanism involving autophagy.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autophagy*
  • Coenzyme A Ligases / metabolism*
  • Drosophila Proteins / metabolism*
  • Longevity*


  • Drosophila Proteins
  • Coenzyme A Ligases