Crizotinib and renal insufficiency: a case report and review of the literature

Paloma Martín Martorell; Marisol Huerta Alvaro; Miguel A Solís Salguero; Amelia Insa Molla

doi:10.1016/j.lungcan.2014.03.001

Crizotinib and renal insufficiency: a case report and review of the literature

Lung Cancer. 2014 Jun;84(3):310-3. doi: 10.1016/j.lungcan.2014.03.001. Epub 2014 Mar 12.

Authors

Paloma Martín Martorell¹, Marisol Huerta Alvaro², Miguel A Solís Salguero³, Amelia Insa Molla²

Affiliations

¹ Department of Hematology and Medical Oncology, Hospital Clínico Universitario de Valencia, Avda. Blasco Ibáñez 17, 46010 Valencia, Spain. Electronic address: paloma_martin@comv.es.
² Department of Hematology and Medical Oncology, Hospital Clínico Universitario de Valencia, Avda. Blasco Ibáñez 17, 46010 Valencia, Spain.
³ Department of Nephrology, Hospital Clínico Universitario de Valencia, Avda. Blasco Ibáñez 17, 46010 Valencia, Spain.

PMID: 24703892
DOI: 10.1016/j.lungcan.2014.03.001

Abstract

A 69 year old man with idiopathic chronic kidney disease was diagnosed with relapsing EGFR negative, ALK positive lung adenocarcinoma, and treated with chemotherapy and antiangiogenic treatment, under which his renal insufficiency worsened. During second line crizotinib treatment, further worsening of the renal function was seen, with very clear correlation with crizotinib withdrawal and rechallenge. No further drug causes for the worsening blood creatinine values were detected.

Keywords: ALK; Crizotinib; Lung adenocarcinoma; Renal insufficiency; Toxicity; Tyrosine kinase inhibitors.

Publication types

Case Reports
Review

MeSH terms

Adenocarcinoma / drug therapy*
Adenocarcinoma of Lung
Aged
Crizotinib
Humans
Kidney Function Tests
Lung Neoplasms / drug therapy*
Male
Protein Kinase Inhibitors / adverse effects*
Pyrazoles / adverse effects*
Pyridines / adverse effects*
Renal Insufficiency / chemically induced*

Substances

Protein Kinase Inhibitors
Pyrazoles
Pyridines
Crizotinib