Obesity and dementia: adipokines interact with the brain

Eur Neuropsychopharmacol. 2014 Dec;24(12):1982-99. doi: 10.1016/j.euroneuro.2014.03.002. Epub 2014 Mar 20.

Abstract

Obesity is a pandemic and a serious global health concern. Obesity is a risk factor for multiple conditions and contributes to multi-morbidities, resulting in increased health costs and millions of deaths each year. Obesity has been associated with changes in brain structure, cognitive deficits, dementia and Alzheimer׳s disease. Adipokines, defined as hormones, cytokines and peptides secreted by adipose tissue, may have more widespread influence and functionality in the brain than previously thought. In this review, six adipokines, and their actions in the obese and non-obese conditions will be discussed. Included are: plasminogen activator inhibitor-1 (PAI-1), interleukin-6 (IL-6), tumor necrosis factors alpha (TNF-α), angiotensinogen (AGT), adiponectin and leptin. Their functionality in the periphery, their ability to cross the blood brain barrier (BBB) and their influence on dementia processes within the brain will be discussed.

Keywords: Adipokines; Alzheimer; Brain; Dementia; Leptin; Obesity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipokines / metabolism*
  • Adiponectin / metabolism
  • Angiotensinogen / metabolism
  • Animals
  • Brain / metabolism*
  • Brain / physiopathology
  • Dementia / complications
  • Dementia / physiopathology*
  • Humans
  • Interleukin-6 / metabolism
  • Leptin / metabolism
  • Models, Biological
  • Obesity / complications
  • Obesity / physiopathology*
  • Plasminogen Activator Inhibitor 1 / metabolism
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Adipokines
  • Adiponectin
  • Interleukin-6
  • Leptin
  • Plasminogen Activator Inhibitor 1
  • Tumor Necrosis Factor-alpha
  • Angiotensinogen