PTH: Potential role in management of heart failure

Clin Chim Acta. 2014 Jun 10:433:290-6. doi: 10.1016/j.cca.2014.03.029. Epub 2014 Apr 1.

Abstract

Biomarkers play an important role for the diagnosis and prognosis of heart failure (HF), a disease with high morbidity and mortality as well as a huge impact on healthcare budgets. Parathyroid hormone (PTH) is a major systemic calcium-regulating hormone and an important regulator of bone and mineral homeostasis. PTH testing is important for differential diagnosis of calcemia related disorders and for the management of patients with chronic kidney disease. As secondary hyperparathyroidism has been evidenced in HF patients, PTH testing might be relevant in HF patients for risk stratification and more personalized selection of treatment.

Keywords: Aldosterone; BNP; FGF-23; Heart failure; Multimarker; Parathyroid hormone.

Publication types

  • Review

MeSH terms

  • Animals
  • Fibroblast Growth Factor-23
  • Heart Failure / blood
  • Heart Failure / diagnosis
  • Heart Failure / metabolism*
  • Heart Failure / therapy
  • Humans
  • Myocardium / metabolism
  • Parathyroid Hormone / blood
  • Parathyroid Hormone / metabolism*

Substances

  • FGF23 protein, human
  • Parathyroid Hormone
  • Fibroblast Growth Factor-23