Improvement of preclinical animal models for autoimmune-mediated disorders via reverse translation of failed therapies

Drug Discov Today. 2014 Sep;19(9):1394-401. doi: 10.1016/j.drudis.2014.03.023. Epub 2014 Apr 2.

Abstract

The poor translational validity of autoimmune-mediated inflammatory disease (AIMID) models in inbred and specific pathogen-free (SPF) rodents underlies the high attrition of new treatments for the corresponding human disease. Experimental autoimmune encephalomyelitis (EAE) is a frequently used preclinical AIMID model. We discuss here how crucial information needed for the innovation of current preclinical models can be obtained from postclinical analysis of the nonhuman primate EAE model, highlighting the mechanistic reasons why some therapies fail and others succeed. These new insights can also help identify new targets for treatment.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / physiopathology*
  • Disease Models, Animal*
  • Drug Design
  • Encephalomyelitis, Autoimmune, Experimental / physiopathology*
  • Humans
  • Primates
  • Rodentia
  • Species Specificity
  • Translational Medical Research / methods