Abstract
Cross-linking of proteins by advanced glycation endproducts (AGEs) causes a host of pathological conditions but their exact roles are unknown. Cross-linking lysyl AGEs were synthesized and incorporated into two types of collagen peptides. The utility of these cross-linked peptides for biochemical investigations was demonstrated by proteolysis studies and circular dichroism.
MeSH terms
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Chromatography, High Pressure Liquid
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Circular Dichroism
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Collagen / chemistry*
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Collagen / metabolism
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Dimerization
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Glycation End Products, Advanced / chemistry*
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Glycation End Products, Advanced / metabolism
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Glyoxal / chemistry
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Lysine / chemistry
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Pyruvaldehyde / chemistry
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Trypsin / metabolism
Substances
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Glycation End Products, Advanced
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Glyoxal
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Pyruvaldehyde
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Collagen
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Trypsin
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Lysine