Human prostate-specific antigen (APS) is a member of the glandular kallikrein gene family at 19q13

Cytogenet Cell Genet. 1988;48(4):205-7. doi: 10.1159/000132629.


The amino acid sequence of human prostate-specific antigen (APS) suggests that it is a member of the glandular kallikrein subfamily of serine proteases. In the mouse, the kallikrein-like family is localized in a single locus on chromosome 7, while other serine proteases are distributed over a variety of different chromosomes. To investigate the physical relationship between the human kallikrein genes, we have used in situ hybridization and Southern analysis of a human x mouse somatic cell hybrid panel to map the APS gene to 19q13, concordant with the renal kallikrein KLK1 gene. This finding indicates that APS is a member of a human kallikrein-like gene family with analogous organization to that of the mouse.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Neoplasm / genetics*
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 19 / immunology
  • Chromosomes, Human, Pair 19 / ultrastructure*
  • Cloning, Molecular
  • DNA / analysis
  • DNA Probes
  • Gene Expression Regulation
  • Humans
  • Kallikreins / genetics*
  • Male
  • Nucleic Acid Hybridization
  • Prostate / cytology
  • Prostate / metabolism
  • Prostate-Specific Antigen
  • Sequence Homology, Nucleic Acid


  • Antigens, Neoplasm
  • DNA Probes
  • DNA
  • Kallikreins
  • Prostate-Specific Antigen