From conception to delivery: managing the pregnant inflammatory bowel disease patient

World J Gastroenterol. 2014 Apr 7;20(13):3495-506. doi: 10.3748/wjg.v20.i13.3495.


Inflammatory bowel disease (IBD) typically affects patients during their adolescent and young adult years. As these are the reproductive years, patients and physicians often have concerns regarding the interaction between IBD, medications and surgery used to treat IBD, and reproduction, pregnancy outcomes, and neonatal outcomes. Studies have shown a lack of knowledge among both patients and physicians regarding reproductive issues in IBD. As the literature is constantly expanding regarding these very issues, with this review, we provide a comprehensive, updated overview of the literature on the management of the IBD patient from conception to delivery, and provide action tips to help guide the clinician in the management of the IBD patient during pregnancy.

Keywords: Biologics; Inflammatory bowel disease; Neonatal outcomes; Pregnancy.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / adverse effects
  • Aminosalicylic Acid / adverse effects
  • Anti-Bacterial Agents / adverse effects
  • Azathioprine / adverse effects
  • Biological Products / therapeutic use
  • Breast Feeding
  • Cyclosporine / adverse effects
  • Female
  • Fertility
  • Humans
  • Inflammatory Bowel Diseases / complications*
  • Inflammatory Bowel Diseases / genetics
  • Inflammatory Bowel Diseases / therapy*
  • Maternal Exposure
  • Mercaptopurine / adverse effects
  • Methotrexate / adverse effects
  • Pregnancy
  • Pregnancy Complications / therapy*
  • Sulfasalazine / adverse effects


  • Adrenal Cortex Hormones
  • Anti-Bacterial Agents
  • Biological Products
  • Sulfasalazine
  • Aminosalicylic Acid
  • Cyclosporine
  • Mercaptopurine
  • Azathioprine
  • Methotrexate