Developing of Granulomatosis with Polyangiitis during Etanercept Therapy

Case Rep Rheumatol. 2014;2014:210108. doi: 10.1155/2014/210108. Epub 2014 Mar 6.


We describe a 67-year-old woman who developed c-ANCA positive vasculitis with involvement in eyes, skin, kidney, peripheral nerves, and upper and lower airway during treatment with etanercept therapy for rheumatoid arthritis. A diagnosis of Granulomatosis with Polyangiitis was done. Thus, anti-TNF therapy may be associated with the development of ANCA positive vasculitis.