Does loop electrosurgical excision procedure of the uterine cervix affect anti-Müllerian hormone levels?

Biomed Res Int. 2014;2014:875438. doi: 10.1155/2014/875438. Epub 2014 Feb 23.


Background: A delayed time to pregnancy was recently reported for women who had a loop electrosurgical excision procedure (LEEP) to remove cervical intraepithelial neoplasia (CIN) grade 2 or 3. The objective of the current study was to determine if treatment of CIN with LEEP is associated with decreased levels of anti-Müllerian hormone (AMH), a marker of ovarian reserve.

Methods: AMH levels were measured in 18 women treated with LEEP and 18 age-matched controls, who had colposcopy only and did not require LEEP. Cases and controls had their blood drawn at study entry time zero and again 6 months later.

Results: The mean AMH level decreased significantly from baseline to follow-up; however, no significant differences were observed when stratifying by LEEP status, suggesting that both groups experienced a similar decrease in AMH levels during the follow-up period. Although women treated with LEEP had lower overall AMH levels than controls at both baseline and follow-up, these differences were not statistically significant.

Conclusion: Overall, the delayed time to pregnancy observed in women treated with LEEP is likely not due to a LEEP-associated decrease in ovarian reserve as measured by AMH; thus, other mechanism are responsible for the delayed time to pregnancy associated with LEEP.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anti-Mullerian Hormone / biosynthesis
  • Anti-Mullerian Hormone / metabolism*
  • Cervical Intraepithelial Neoplasia / metabolism*
  • Cervical Intraepithelial Neoplasia / pathology
  • Cervical Intraepithelial Neoplasia / surgery
  • Cervix Uteri / metabolism*
  • Cervix Uteri / pathology
  • Cervix Uteri / surgery
  • Electrosurgery / adverse effects*
  • Female
  • Humans
  • Pregnancy


  • Anti-Mullerian Hormone