Metabolic acidosis and the progression of chronic kidney disease

BMC Nephrol. 2014 Apr 3;15:55. doi: 10.1186/1471-2369-15-55.


Metabolic acidosis is a common complication of chronic kidney disease. Accumulating evidence identifies acidosis not only as a consequence of, but as a contributor to, kidney disease progression. Several mechanistic pathways have been identified in this regard. The dietary acid load, even in the absence of overt acidosis, may have deleterious effects. Several small trials now suggest that the treatment of acidosis with oral alkali can slow the progression of kidney disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acidosis / diagnosis
  • Acidosis / etiology*
  • Acidosis / therapy*
  • Citrates / therapeutic use
  • Diet Therapy / methods
  • Disease Progression
  • Humans
  • Renal Insufficiency, Chronic / complications*
  • Renal Insufficiency, Chronic / diagnosis
  • Renal Insufficiency, Chronic / therapy*
  • Risk Factors
  • Sodium Bicarbonate / therapeutic use
  • Sodium Citrate
  • Survival Rate
  • Treatment Outcome


  • Citrates
  • Sodium Citrate
  • Sodium Bicarbonate