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. 2014 May;133(5):e1128-38.
doi: 10.1542/peds.2013-3664. Epub 2014 Apr 7.

Parental obesity and risk of autism spectrum disorder

Pål Surén  1 , Nina Gunnes  2 , Christine Roth  2 , Michaeline Bresnahan  3 , Mady Hornig  4 , Deborah Hirtz  5 , Kari Kveim Lie  6 , W Ian Lipkin  4 , Per Magnus  6 , Ted Reichborn-Kjennerud  7 , Synnve Schjølberg  6 , Ezra Susser  3 , Anne-Siri Oyen  8 , George Davey Smith  9 , Camilla Stoltenberg  10
Affiliations

Parental obesity and risk of autism spectrum disorder

Pål Surén et al. Pediatrics. 2014 May.

Abstract

Objectives: The objective of the study was to investigate the associations among maternal prepregnancy BMI, paternal BMI, and the risk of autism spectrum disorders (ASDs) in children.

Methods: The study sample of 92 909 children was derived from the population-based, prospective Norwegian Mother and Child Cohort Study. The age range was 4.0 through 13.1 (mean 7.4) years. Relative risks of ASDs were estimated by odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regression models.

Results: At the end of follow-up on December 31, 2012, 419 children in the study sample had been diagnosed with ASDs: 162 with autistic disorder, 103 with Asperger disorder, and 154 with pervasive developmental disorder not otherwise specified. Maternal obesity (BMI ≥30) was only weakly associated with ASD risk, whereas paternal obesity was associated with an increased risk of autistic disorder and Asperger disorder. The risk of autistic disorder was 0.27% (25 of 9267) in children of obese fathers and 0.14% (59 of 41 603) in children of fathers with normal weight (BMI <25), generating an adjusted OR of 1.73 (95% CI: 1.07-2.82). For Asperger disorder, analyses were limited to children aged ≥7 years (n = 50 116). The risk was 0.38% (18 of 4761) in children of obese fathers and 0.18% (42 of 22 736) in children of normal-weight fathers, and the adjusted OR was 2.01 (95% CI: 1.13-3.57). No associations were found for pervasive developmental disorder not otherwise specified.

Conclusions: Paternal obesity is an independent risk factor for ASDs in children. The associations should be investigated further in genetic and epigenetic studies.

Keywords: Asperger disorder; PDD-NOS; autism spectrum disorder; autistic disorder; child cohort study; parental BMI; parental obesity.

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Figures

FIGURE 1
FIGURE 1
Risk of autistic disorder according to maternal and paternal BMIs: generalized additive models. In the adjusted models, maternal and paternal BMIs were adjusted for each other and for parental education levels, child’s year of birth, and maternal parity.
FIGURE 2
FIGURE 2
Risk of PDD-NOS according to maternal and paternal BMIs: generalized additive models. In the adjusted models, maternal BMI and paternal BMIs were adjusted for each other and for parental education levels, child’s year of birth, and maternal parity.
FIGURE 3
FIGURE 3
Risk of Asperger disorder according to maternal and paternal BMIs: generalized additive models. In the adjusted models, maternal and paternal BMIs were adjusted for each other and for parental education levels, child’s year of birth, and maternal parity.
FIGURE 4
FIGURE 4
Risk of ASD according to maternal and paternal BMIs: generalized additive models. In the adjusted models, maternal and paternal BMIs were adjusted for each other and for parental education levels, child’s year of birth, and maternal parity.
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