Cyclo-oligo-(1 → 6)-β-D-glucosamine based artificial channels for tunable transmembrane ion transport

Tanmoy Saha; Arundhati Roy; Marina L Gening; Denis V Titov; Alexey G Gerbst; Yury E Tsvetkov; Nikolay E Nifantiev; Pinaki Talukdar

doi:10.1039/c3cc49490j

Cyclo-oligo-(1 → 6)-β-D-glucosamine based artificial channels for tunable transmembrane ion transport

Chem Commun (Camb). 2014 May 28;50(41):5514-6. doi: 10.1039/c3cc49490j.

Authors

Tanmoy Saha¹, Arundhati Roy, Marina L Gening, Denis V Titov, Alexey G Gerbst, Yury E Tsvetkov, Nikolay E Nifantiev, Pinaki Talukdar

Affiliation

¹ Department of Chemistry, Indian Institute of Science Education and Research Pune, Maharashtra 411008, India. ptalukdar@iiserpune.ac.in.

PMID: 24710000
DOI: 10.1039/c3cc49490j

Abstract

Unimolecular ion channels were designed by functionalization of a new type of cyclic oligosaccharides, cyclo-oligo-(1 → 6)-β-d-glucosamines, with pentabutylene glycol chains. Their ion transporting activity was tuned by varying oligomericity. A halide selectivity sequence, Cl(-) > Br(-) > I(-) was observed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomimetic Materials / chemistry*
Carbohydrate Conformation
Cell Membrane / metabolism*
Glucosamine / chemistry*
Ion Transport
Molecular Dynamics Simulation
Oligosaccharides / chemistry*

Substances

Oligosaccharides
Glucosamine