How cyclobutanes are assembled in nature--insights from quantum chemistry

Chem Soc Rev. 2014 Jul 21;43(14):5042-50. doi: 10.1039/c3cs60452g.

Abstract

Biosynthetic production of cyclobutanes leads to many complex natural products. Recently, theoretical work employing quantum chemical calculations has shed light on many of the details of cyclobutane-formation, in particular, for terpene natural products. Specific insights and general principles derived from these theoretical studies are described herein.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Biological Products
  • Cyclobutanes / chemistry*
  • Cyclobutanes / metabolism*
  • Models, Chemical*
  • Organic Chemistry Phenomena*
  • Photochemical Processes
  • Terpenes / chemistry
  • Terpenes / metabolism

Substances

  • Biological Products
  • Cyclobutanes
  • Terpenes