Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 20 (3), 482-9

Extinction of a Cocaine-Taking Context That Protects Against Drug-Primed Reinstatement Is Dependent on the Metabotropic Glutamate 5 Receptor

Affiliations

Extinction of a Cocaine-Taking Context That Protects Against Drug-Primed Reinstatement Is Dependent on the Metabotropic Glutamate 5 Receptor

Jee Hyun Kim et al. Addict Biol.

Abstract

We investigated the effects of extinguishing action-reward versus context-reward associations on drug-primed reinstatement, and the potential role of the metabotropic glutamate 5 receptor (mGlu5) in these different types of extinction in rats that self-administer cocaine. We observed that daily context extinction (non-reinforced exposures to the cocaine-taking context with retracted levers) was just as effective as daily lever extinction in reducing cocaine-primed reinstatement compared with passive abstinence. Additionally, systemic injections of the mGlu5 negative allosteric modulator MTEP (3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine) following each extinction session significantly impaired the ability of context extinction to reduce cocaine-primed reinstatement, without affecting reinstatement after lever extinction or passive abstinence.

Keywords: Abstinence; MTEP; addiction; context; extinction; mGlu5.

Similar articles

See all similar articles

Cited by 9 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback