Interferon-stimulated genes: roles in viral pathogenesis

Curr Opin Virol. 2014 Jun:6:40-6. doi: 10.1016/j.coviro.2014.03.006. Epub 2014 Apr 5.


Interferon-stimulated genes (ISGs) are critical for controlling virus infections. As new antiviral ISGs continue to be identified and characterized, their roles in viral pathogenesis are also being explored in more detail. Our current understanding of how ISGs impact viral pathogenesis comes largely from studies in knockout mice, with isolated examples from human clinical data. This review outlines recent developments on the contributions of various ISGs to viral disease outcomes in vivo.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation / drug effects*
  • Host-Pathogen Interactions* / drug effects
  • Host-Pathogen Interactions* / genetics
  • Humans
  • Interferons / metabolism
  • Interferons / pharmacology*
  • Virus Diseases / genetics*
  • Virus Diseases / metabolism
  • Virus Diseases / virology*
  • Viruses / pathogenicity*


  • Interferons