Neuropeptides and inflammation: the role of substance P

Annu Rev Med. 1989;40:341-52. doi: 10.1146/


The neuropeptide substance P modulates the activities of a number of different leukocytes that characterize both acute and delayed inflammatory responses. Substance P may play a role in the pathogenesis of such diverse diseases as arthritis, asthma, and inflammatory bowel disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Hypersensitivity, Delayed / physiopathology
  • Hypersensitivity, Immediate / physiopathology
  • Inflammation / physiopathology*
  • Mononuclear Phagocyte System / drug effects
  • Muscle, Smooth / drug effects
  • Receptors, Neurokinin-1
  • Receptors, Neurotransmitter / drug effects
  • Substance P / physiology*


  • Receptors, Neurokinin-1
  • Receptors, Neurotransmitter
  • Substance P