Abstract
N-Heterocyclic carbene (NHC) catalyzed lactonization and lactamization of 2-bromoenals with heterocyclic C-H acids proceeding via the α,β-unsaturated acyl azolium intermediates is reported. The reaction furnished coumarin- or quinolinone-fused lactone/lactam derivatives. In addition, results of the enantioselective version of this reaction using chiral NHC are presented.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acids / chemistry*
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Catalysis
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Coumarins / chemical synthesis*
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Coumarins / chemistry
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Heterocyclic Compounds / chemistry*
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Methane / analogs & derivatives*
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Methane / chemistry
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Molecular Structure
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Quinolones / chemical synthesis*
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Quinolones / chemistry
Substances
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Acids
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Coumarins
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Heterocyclic Compounds
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Quinolones
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carbene
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Methane