Stochastic genome-nuclear lamina interactions: modulating roles of Lamin A and BAF

Nucleus. Mar-Apr 2014;5(2):124-30. doi: 10.4161/nucl.28825. Epub 2014 Apr 9.

Abstract

The nuclear lamina (NL) is thought to aid in the spatial organization of interphase chromosomes by providing an anchoring platform for hundreds of large genomic regions named lamina associated domains (LADs). Recently, a new live-cell imaging approach demonstrated directly that LAD-NL interactions are dynamic and in part stochastic. Here we discuss implications of these new findings and introduce Lamin A and BAF as potential modulators of stochastic LAD positioning.

Keywords: BAF; LADs; Lamin A; Lamin B1; chromatin domains; nuclear organization; single cell.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chromatin / metabolism
  • DNA-Binding Proteins / metabolism*
  • Genome*
  • Humans
  • Lamin Type A / metabolism*
  • Nuclear Lamina / metabolism*
  • Stochastic Processes

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Lamin Type A