Circulating TNF receptor 2 is closely associated with the kidney function in non-diabetic Japanese subjects

J Atheroscler Thromb. 2014;21(7):730-8. doi: 10.5551/jat.21055. Epub 2014 Apr 8.

Abstract

Aim: Chronic kidney disease (CKD) is associated with cardiovascular events. Tumor necrosis factor (TNF) and/or its receptors have been postulated to be involved in renal pathophysiology. It is unclear whether an increased TNF system activity is present before the development of apparent CKD.

Methods: Four hundred and twenty non-diabetic Japanese subjects with an estimated GFR (eGFR) greater than 60 ml/min/1.73 m(2) were recruited for measurement of the HbA1c, insulin, TNF system activity (TNF-α, soluble TNF receptor 1 (sTNF-R1) and sTNF-R2) levels and various parameters, including the lipid, high-sensitivity C-reactive protein (hsCRP), high-molecular-weight (HMW) adiponectin and leptin levels. The subjects were stratified according to the eGFR: the G1 level (eGFR ≧90 ml/min/1.73 m(2)) and the G2 level (90 >eGFR ≧60 ml/min/1.73 m(2)).

Results: Whereas no significant differences were observed in gender, body mass index (BMI), blood pressure, insulin, TNF-α, hsCRP, HMW adiponectin or leptin between the two groups, the values for age, HbA1c, triglycerides, sTNF-R1 and sTNF-R2 were significantly higher in the subjects with a G2 level of eGFR than in those with a G1 level. In contrast, the HDL cholesterol levels were significantly lower in the subjects with a G2 level than in those with a G1 level. Linear negative correlations were also observed between eGFR and age, BMI, HbA1c, triglycerides, sTNF-R1 and sTNFR2, respectively. A multiple logistic regression analysis revealed that only sTNF-R2 was associated with the presence of a G2 level of eGFR (Odds ratio 1.092, 95% CI 1.013-1.177, P=0.021).

Conclusions: The circulating sTNF-R2 level is closely associated with the kidney function in non-diabetic Japanese subjects.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers / blood*
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate
  • Humans
  • Inflammation Mediators / blood
  • Kidney Diseases / blood*
  • Kidney Diseases / diagnosis*
  • Male
  • Middle Aged
  • Prognosis
  • Receptors, Tumor Necrosis Factor, Type I / blood*
  • Receptors, Tumor Necrosis Factor, Type II / blood*
  • Triglycerides / blood
  • Tumor Necrosis Factor-alpha / blood*

Substances

  • Biomarkers
  • Inflammation Mediators
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor, Type II
  • Triglycerides
  • Tumor Necrosis Factor-alpha