Clinical application of indocyanine green angiography to choroidal neovascularization

Jpn J Ophthalmol. 1989;33(1):57-65.


In order to evaluate the clinical usefulness of indocyanine green video-angiography (IA), the angiographic features of choroidal neovascular membranes (CNM) were investigated in 27 eyes with choroidal neovascular diseases by means of standard fluorescein angiography (FA) and IA. FA showed the existence of CNM in 21 eyes and IA demonstrated evidence of CNM in 19 eyes, as "fan, comb or spotty hyperfluorescence" in the early stage and "leakage" in the late stage. In 6 out of 19 eyes the existence of CNM was shown by IA, while FA failed to identify the precise location and size of CNM due to the masking effect of overlying turbid fluid, massive hemorrhage or a large amount of serous fluid. The results imply that IA has an advantage over FA in cases where FA shows only the sign of occult choroidal neovascularization, and that IA can be applied to neovascular maculopathy as a routine examination.

Publication types

  • Comparative Study

MeSH terms

  • Choroid / blood supply*
  • Fluorescein Angiography
  • Humans
  • Indocyanine Green*
  • Macular Degeneration / diagnosis
  • Neovascularization, Pathologic / diagnosis*


  • Indocyanine Green