Aggravation of hypertriglyceridemia and acute pancreatitis in a bipolar patient treated with quetiapine

Yonsei Med J. 2014 May;55(3):831-3. doi: 10.3349/ymj.2014.55.3.831. Epub 2014 Apr 1.


Pancreatitis is a very rare adverse effect of quetiapine treatment, with only 5 cases of quetiapine-associated pancreatitis reported in the English literature to date. Herein, we report one patient who developed severe hypertriglyceridemia (>1000 mg/dL) after quetiapine administration, resulting in acute pancreatitis. An analysis of the underlying pathogenic mechanisms and a review of relevant literature are also presented. Clinicians should be aware of the potentially life-threatening metabolic disturbances and/or pancreatitis associated with quetiapine therapy.

Keywords: Quetiapine; hypertriglyceridemia; pancreatitis.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Bipolar Disorder / drug therapy*
  • Bipolar Disorder / psychology*
  • Dibenzothiazepines / therapeutic use*
  • Humans
  • Hypertriglyceridemia / drug therapy*
  • Hypertriglyceridemia / psychology*
  • Pancreatitis / drug therapy*
  • Pancreatitis / psychology*
  • Quetiapine Fumarate


  • Dibenzothiazepines
  • Quetiapine Fumarate